Evidence map›Paper›PMID 42028659›Full record

ReviewBioMed research international2026

Exploring the Cancer Therapeutic Potential of Traditional Medicinal Plants by Modulating the Apoptotic Pathway.

Mithila Kulkarni, Mohammad Amjad Hussain, Reginald Samson Valdar, Shreya Hebbar, Suparna Laha

Abstract readReview
In one paragraph

Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mithila KulkarniCell Biology and Molecular Genetics Division, Yenepoya Research Centre, Yenepoya (Deemed To Be University), Mangalore, Karnataka, India.ORCID https://orcid.org/0000-0003-0854-5438
Mohammad Amjad HussainCell Biology and Molecular Genetics Division, Yenepoya Research Centre, Yenepoya (Deemed To Be University), Mangalore, Karnataka, India.ORCID https://orcid.org/0009-0000-2767-7781
Reginald Samson ValdarCell Biology and Molecular Genetics Division, Yenepoya Research Centre, Yenepoya (Deemed To Be University), Mangalore, Karnataka, India.ORCID https://orcid.org/0009-0007-1171-2002
Shreya HebbarCell Biology and Molecular Genetics Division, Yenepoya Research Centre, Yenepoya (Deemed To Be University), Mangalore, Karnataka, India.ORCID https://orcid.org/0009-0001-7874-9981
Suparna LahaCell Biology and Molecular Genetics Division, Yenepoya Research Centre, Yenepoya (Deemed To Be University), Mangalore, Karnataka, India.ORCID https://orcid.org/0000-0001-9355-1714

Funding

Yenepoya University 132-2022
6 · The paper itself

Abstract

introductionCancer is a versatile disease with a high rate of relapse and mortality. Despite the presence of various treatment modalities, there is a serious need for the development of its management. Phytochemicals, which are abundant in nature, can be turned into novel medications for these types of diseases by optimizing their functions and structures. Therefore, a thorough understanding of traditional medicine and medicinal plants may lead to the discovery of new and affordable medicines. Many studies have shown that a variety of medicinal plants and nutraceuticals derived from different natural resources, along with their byproducts, such as flavones, flavonoids, antioxidants, and major polyphenolic constituents, offer significant protection against a wide range of cancers. These dietary compounds may function as chemopreventive agents, as they have been shown to possess an inhibitory effect on cancer cells. METHODOLOGY: A comprehensive literature review was conducted to identify medicinal plants traditionally used for their anticancer properties. Studies presenting molecular evidence for the mechanisms of action of these plants were critically analyzed and selected for inclusion.

resultsOur analysis of the available research data on ethnic medicinal plants revealed that they affect selective pathways, such as the cell cycle, proliferation, apoptosis, metastasis, angiogenesis, and phagocytosis, leading to tumor-static and cell death of cancer cells.

conclusionA wide range of traditional plants have been utilized for the treatment of different diseases, including cancer. Despite the presence of various anticancer medicinal plants, only a few have advanced beyond the laboratory and are used clinically. This is primarily due to the lack of knowledge regarding their mode of action at the molecular level. By understanding the molecular mechanisms, these traditionally used medicines can be translated into drugs and used to manage diseases such as cancer.

Indexed as

ApoptosisMedicine, TraditionalNeoplasmsPlants, MedicinalAnimalsHumansPhytochemicalsPlant ExtractsPhytochemicalsPlant ExtractsapoptosisBAX/BCL-2cancer severitygenomic instabilityphytochemicals

Identifiers

PMID42028659
PMCPMC13107168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.