Evidence map›Paper›PMID 42028649›Full record

Trial reportTransactions of the Royal Society of Tropical Medicine and Hygiene2026

Lessons from the field: implementing an electronic clinical decision support app for acute febrile illness in rural Cambodia.

Abhijit Mishra, Elke Wynberg, Marco Liverani, Moul Vanna, Phal Chanpheakdey, Chea Nguon, James J Callery, Bipin Adhikari, Rupam Tripura, Arjun Chandna and 10 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Abhijit MishraMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0009-0001-7311-2041
Elke WynbergMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Marco LiveraniMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Moul VannaAction for Health Development, Battambang 021404, Cambodia.
Phal ChanpheakdeyMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Chea NguonNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh 12101, Cambodia.
James J CalleryMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Bipin AdhikariMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0001-8981-3910
Rupam TripuraMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Arjun ChandnaCentre for Tropical Medicine and Global Health, University of Oxford, Oxford OX3 7LF, UK.ORCID 0000-0003-1313-7922
Greg FeganMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Naomi WaithiraMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Thomas J PetoMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Bunreth VoeurngProvincial Health Department, Battambang 021410, Cambodia.
Chan DavoengProvincial Health Department, Battambang 021410, Cambodia.
Huy RekolNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh 12101, Cambodia.
Lek DysoleyNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh 12101, Cambodia.
Nicholas P J DayMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Yoel LubellMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Rusheng ChewMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-8992-4474

Funding

Australasian Society for Infectious DiseasesWellcome Trust 215604/Z/19/Z
6 · The paper itself

Abstract

To improve the management of acute febrile illness in rural low- and middle-income country (LMIC) primary care settings, we developed the Electronic clinical Decision support for Acute fever Management (EDAM) app and evaluated it through a cluster-randomised trial in rural Cambodian primary health centres (PHCs). In parallel, we conducted structured, mixed methods observations at a subset of participating PHCs to document key challenges in screening, enrolling and managing patients. A key lesson was the critical importance of user-centred design to align digital tools with health worker workflows and capabilities. The lessons from these observations may help guide researchers and policymakers developing novel digital health solutions for low- and semi-skilled health workers in rural LMIC settings. Our experiences could offer valuable insights, as there are few documented digital health interventions designed for these contexts. Furthermore, navigating the challenges of implementation and subsequent evaluation remains a significant hurdle for the field.

Indexed as

Decision Support Systems, ClinicalFeverMobile ApplicationsAcute DiseaseCambodiaDigital HealthHumansPrimary Health CareResource-Limited SettingsRural Health ServicesRural Populationacute febrile illnessantimicrobial resistanceCambodiaclinical decision supportdigital healthfield lessonsimplementation challengesprimary care

Identifiers

PMID42028649
PMCPMC7619126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.