ArticleCureus2026
Changing Trends in the Fungal Aetiology of Chronic Suppurative Otitis Media and Antifungal Susceptibility Patterns of Isolated Fungi: A Pilot Study From a Tertiary Care Centre in Central India.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Middle-ear and mastoid mucosal inflammation that persists for at least six weeks with discharge is known as chronic suppurative otitis media (CSOM). It is prevalent in India, and fungal infections contribute to a notable proportion of cases. Irrational use of steroids and antibiotics is associated with increased fungal isolates. This study aims to evaluate the presence, profile, and antifungal susceptibility (AFST) of fungi in CSOM patients, using Sensititre™ YeastOne® (Thermo Fisher Scientific, Waltham, MA, USA) colorimetric broth microdilution for yeasts and disk diffusion for moulds, although bacterial causes are well established. Materials and methods This study was a one-year cross-sectional study conducted in the Department of Microbiology in collaboration with the Departments of Microbiology and ENT-Head & Neck Surgery. This one-year cross-sectional study included patients aged 12 years or older with purulent ear discharge lasting at least six weeks. Samples of middle ear exudate were gathered and prepared for mounting and culture in 10%-20% potassium hydroxide (KOH). Isolates of yeast or mould were identified at the species level using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS; Bruker Daltonics, Bremen, Germany). For the isolated yeasts, AFST was performed using the Sensititre™ YeastOne® colourimetric broth microdilution method in accordance with the CLSI M27-A3 standard, and results were interpreted according to the M60 guideline. The data were collected in an Excel sheet (Microsoft® Corp., Redmond, WA, USA), and the statistical analysis involved both descriptive and inferential techniques. Results A total of 136 clinical samples were analyzed in the study. Of these, 27 (19.9%) were KOH positive, including 12 (44.4%) that were culture negative. Overall, 30 samples (22.1%) were culture positive, of which 15 (50%) were KOH negative. The overall fungal prevalence in the study was 42 (30.9%). Among the 30 culture-positive cases, six (20%) were moulds, and 24 (80%) were yeasts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.