ArticleFrontiers in integrative neuroscience2026
Synergistic efficacy of combined neurolysis and methylcobalamin in peripheral nerve injury: a randomized clinical trial.
Article in Frontiers in integrative neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Peripheral nerve injury (PNI) imposes significant burdens, requiring therapies targeting both mechanical compression and inflammatory pathophysiology. While neurolysis addresses extrinsic compression and methylcobalamin promotes intrinsic nerve repair, their combined potential is underexplored. This study compared the efficacy of neurolysis monotherapy, methylcobalamin monotherapy, and combination therapy across functional, electrophysiological, and inflammatory outcomes in PNI. Methods: Ninety PNI patients were randomized to three groups ( Results: The combination group demonstrated significantly higher total therapeutic efficacy (86.67%) compared to neurolysis alone (50.00%) and methylcobalamin alone (53.33%; Discussion: The combination of neurolysis and methylcobalamin synergistically enhances functional recovery, nerve conduction, joint mobility, pain relief, and anti-inflammatory effects in PNI, demonstrating superior clinical efficacy compared to either treatment administered alone.
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