SynthesisFrontiers in pharmacology2026
Trilaciclib for prophylaxis of chemotherapy-induced myelosuppression in solid tumor patients: a systematic review and meta-analysis.
Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate the clinical benefit and safety of trilaciclib in solid-tumor patients receiving chemotherapy and to inform clinical practice. Methods: Following PRISMA guidelines and registered at PROSPERO (CRD420251053232), we searched PubMed, Embase and two other databases from inception to June 2025. Six randomized controlled trials enrolling 726 patients were included. Meta-analyses were performed with Review Manager 5.4. Results: Trilaciclib significantly reduced the incidence of severe neutropenia (SN) and febrile neutropenia (FN), shortened SN duration, and decreased the need for erythropoiesis-stimulating agents (ESAs), granulocyte colony-stimulating factor (G-CSF) and red-blood-cell (RBC) transfusions while lowering anemia rates. These benefits were not accompanied by increased risks of nausea, vomiting or fatigue. Progression-free survival (PFS) was significantly prolonged, whereas overall survival (OS) remained unchanged; patients aged ≥65 years and those enrolled in U.S. trials derived the greatest benefit. Limitations include the small number of RCTs, heterogeneous chemotherapy regimens, potential publication bias and short follow-up in some studies. Conclusion: Trilaciclib effectively prevents chemotherapy-induced myelosuppression in solid-tumor patients and can guide clinical use, but further well-designed studies are warranted to consolidate its efficacy and safety profile. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251053232URL.
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