Evidence map›Paper›PMID 42028433›Full record

ArticleFrontiers in pharmacology2026

Evaluation of the efflux inhibitory potential of gallotannin to restore drug sensitivity in XDR

Ramaravinth Manivannan, Niraimathi Muralidharan, Sadhiskumar Balavarun, Y B R D Rajesh, Aravind Sivasubramanian, Subramanian Muthukumar, Saisubramanian Nagarajan

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ramaravinth ManivannanSchool of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Niraimathi MuralidharanSchool of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Sadhiskumar BalavarunSchool of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Y B R D RajeshDepartment of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Aravind SivasubramanianDepartment of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Subramanian MuthukumarSchool of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.
Saisubramanian NagarajanSchool of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: The efflux inhibitory potential of 13 plant-derived polyphenols was evaluated to restore antibiotic susceptibility in MDR/XDR clinical isolates of Results and Discussion: Gallotannin exhibited the strongest activity, achieving a 64-fold reduction in erythromycin MIC in an XDR strain. Efflux inhibition was confirmed through real-time efflux and accumulation assays, showing 32-64-fold MIC reductions across multiple antibiotic classes in five MDR/XDR isolates. Molecular simulations revealed stable binding of gallotannin to the AdeB efflux pump via persistent hydrogen bonding. Combination therapy resulted in a ∼5-log CFU reduction

Indexed as

Acinetobacter baumanniiAdeB transporterantibiotic potentiationefflux pump inhibitiongallotanninMultidrug resistance (MDR/XDR)Reactive oxygen species (ROS)zebrafish infection model

Identifiers

PMID42028433
PMCPMC13099881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.