ArticleCentral-European journal of immunology2025
Dexmedetomidine inhibits the Wnt/β-catenin pathway, regulates ferroptosis in bladder cancer cells and the tumor immune microenvironment, and suppresses tumorigenesis in a mouse bladder cancer model.
Article in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study aimed to explore the antitumor effects of dexmedetomidine (Dex) in bladder cancer, focusing on its role in modulating ferroptosis and the tumor immune microenvironment. Material and methods: Bladder cancer cell lines (T24 and RT4) were treated with various concentrations of Dex, followed by analysis of cell proliferation, ferroptosis markers, and immune evasion factors. In vivo, a mouse xenograft model of bladder cancer was used to assess tumor growth and related molecular mechanisms. Western blotting, flow cytometry, immunohistochemistry, and ELISA were used to evaluate protein expression levels, immune cell activity and cytokine production. Results: Dex significantly inhibited bladder cancer cell proliferation and promoted ferroptosis by increasing intracellular Fe Conclusions: Dexmedetomidine exerted antitumor effects in bladder cancer by inducing ferroptosis and modulating the tumor immune microenvironment through suppression of the Wnt/
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