Evidence map›Paper›PMID 42028393›Full record

ArticleCentral-European journal of immunology2025

Paeoniflorin inhibits degranulation of mast cells through suppressing the cGAS/STING signaling pathway.

Guanli Song, Guanbo Song, Xiaji Zhou, Lei Zhang

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In one paragraph

Article in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guanli Song *Department of Preventive and Health Care, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China.
Guanbo Song *Department of Clinical Laboratory, Jining Chinese Medicine Hospital, Jining, Shandong, P.R. China.
Xiaji ZhouDepartment of Prestigious TCM Doctors' Experiences, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China.
Lei ZhangNational Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Allergic rhinitis is an allergic disease that affects the nasal mucosa, and its incidence has been increasing significantly in recent years. Paeoniflorin (PF) is the main chemical component of total glucosides of paeony and is reported to have an excellent effect on anti-allergic inflammation. In this study, we aimed to investigate the mechanism of PF regulating the degranulation of mast cells induced by dinitrophenol (DNP)-human serum albumin (DNP-HSA). Material and methods: The effect of PF on the degranulation of mast cells was evaluated through the measurement of histamine, Results: The results showed that PF treatment reduced the release of histamine and Conclusions: In conclusion, PF inhibits degranulation of mast cells through the cGAS/STING signaling pathway, which provides a theoretical basis for the application of PF in allergic rhinitis therapy.

Indexed as

allergic rhinitiscGAS/STINGhistaminemast cellspaeoniflorin

Identifiers

PMID42028393
PMCPMC13100591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.