Evidence map›Paper›PMID 42028390›Full record

ArticleCentral-European journal of immunology2025

Intestinal CD8+ γδ T cells shift from immune activation to suppression, with concomitant impairment of cytotoxicity as disease activity increases in patients with ulcerative colitis.

Jia Zhu, Tao Zhu, Caixia Sheng, Tingting Zhong, Jiaqi Xu, Xiaoqing Cheng, Jin Wang, Guoxiang Fu, Zhinong Jiang, Yujie Jiang

Abstract read
In one paragraph

Article in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia ZhuSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Tao ZhuSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Caixia ShengSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Tingting ZhongSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Jiaqi XuSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Xiaoqing ChengSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Jin WangSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Guoxiang FuSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Zhinong JiangSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.
Yujie JiangSir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Ulcerative colitis (UC) is a persistent inflammatory intestinal condition characterized by fluctuating disease activity (DA), with incompletely understood immunopathogenesis. Material and methods: Our analysis included employing flow cytometry to examine CD8+ Results: A marked decline in the levels of IM CD8+ Conclusions: Our findings demonstrate the progression from immune activation to suppression and the concomitant impairment of cytotoxic activity in intestinal CD8+

Indexed as

CD8+ γδ T cellscytotoxicitydisease activityimmune statusulcerative colitis

Identifiers

PMID42028390
PMCPMC13100587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.