Evidence map›Paper›PMID 42028385›Full record

ArticleCentral-European journal of immunology2025

KLF7 enhances the inflammatory response in LPS-induced alveolar epithelial cells

Bing Huang, Yanchao Liang, Fangwei Chen, Juan Zhou, Cancan Xie

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Article in Central-European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Bing Huang *Respiratory and Critical Care Discipline Zone 1, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.
Yanchao Liang *Respiratory and Critical Care Discipline Zone 3, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.
Fangwei ChenRespiratory and Critical Care Discipline Zone 1, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.
Juan ZhouRespiratory and Critical Care Discipline Zone 3, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.
Cancan XieIntensive Care Medicine Department, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou 412007, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Krüppel-like factor 7 (KLF7) exhibits pro-inflammatory properties in numerous diseases, but its precise function in acute lung injury (ALI) remains ambiguous. This study aimed to elucidate the molecular mechanism of KLF7 in type II alveolar epithelial cells under ALI conditions. Material and methods: Cell Counting Kit-8 (CCK-8) assay and flow cytometry were employed to assess cell viability and apoptosis. The binding of KLF7 and LIM kinase 1 (LIMK1) promoter was tested by ChIP and dual-luciferase assays. GST pull-down and Co-IP assays verified the interaction between LIMK1 and serine arginine protein kinase 1 (SRPK1). Levels of inflammatory cytokines were measured by ELISA test. Western blot and quantitative real-time PCR were applied to assess the expression of related factors. Results: KLF7 was upregulated in LPS-treated alveolar epithelial cells, and its knockdown attenuated cell apoptosis and inflammation by promoting cell viability and decreasing tumor necrosis factor Conclusions: KLF7 intensified the inflammatory response of alveolar epithelial cells under ALI conditions by modulating the LIMK1/SRPK1 axis.

Indexed as

acute lung injuryinflammatory responseKLF7LIMK1SRPK1

Identifiers

PMID42028385
PMCPMC13100582

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