ArticleClinical and translational radiation oncology2026
Single fraction based-partial breast irradiation: 10-year results of the SiFEBI phase 2 prospective trial.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01727011 (A Phase I-II Trial Evaluating the Toxicity of Early Breast Partial Irradiation in Patients Aged at Least of 70 Years With Breast Cancer at Low Risk of Local Recurrence), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase I-II Trial Evaluating the Toxicity of Early Breast Partial Irradiation in Patients Aged at Least of 70 Years With Breast Cancer at Low Risk of Local Recurrence
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This analysis updates the SiFEBI phase 2 trial (NCT01727011) evaluating accelerated partial breast irradiation (APBI) delivered as a single fraction (sfPBI) of postoperative multicatheter interstitial HDR brachytherapy (MIB) in elderly patients with low-risk breast cancer. Materials and methods: Patients aged ≥ 70 years (Balducci I-II) with low-risk breast cancer were enrolled. After lumpectomy, intraoperative catheter implantation was performed and postoperative sfPBI (16 Gy) was delivered. The primary endpoint was cumulative incidence of local recurrence (ciLR). Secondary endpoints included cumulative incidence of distant metastasis (ciDM), cancer-specific survival (CSS), overall survival (OS), late toxicity, cosmetic outcome, and endocrine-therapy (ET) adherence. Results: From 11/12 to 09/14, 26 patients were enrolled. Median age was 76.6 years; median tumour size was 10.4 mm. Most tumours were invasive ductal carcinoma (76.5%), all of luminal subtype. After a median follow-up of 137 months, 10-year ciLR was 5%. Ten-year ciDM, CSS, and OS were 0%, 100%, and 81%, respectively. Late toxicity was observed in 9 patients (34.6%) with a total of 12 events (G1: 83.3%, G2: 16.6%). Reported late effects included breast pain, hypopigmentation, telangiectasia and breast fibrosis. Ten-year cosmetic outcomes were reported in 18 pts as excellent in 14 patients (77.8%) and good in 4 patients (22.2%). Median ET duration was 59 months; 14 pts (53.8%) were non-adherent. Conclusion: In this elderly, low-risk cohort, single fraction postoperative MIB sfPBI provided excellent long-term oncological outcomes with acceptable toxicity and cosmesis. Larger studies with extended follow-up are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.