Stress Hyperglycemia Ratio as a Predictor of All-Cause and Cardiovascular Mortality in the General Population: Insights From NHANES 2001-2018.

Lei Zhang, Chang Shu, WenTao Hu, WanCheng Guo, PengCheng Guo, Rui Li, Dexiang Xia, Xin Li

Abstract read

In one paragraph

Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

Stress Hyperglycemia Ratio as a Predictor of All-Cause and Cardiovascular Mortality in the General Population: Insights From NHANES 2001-2018.International journal of endocrinology · 2026
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8 authors.

Lei ZhangDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-7238-6999

Chang ShuDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-5096-4655

WenTao HuDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0009-0007-4553-1680

WanCheng GuoDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0009-0004-8896-9410

PengCheng GuoDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0009-0007-0183-7194

Rui LiDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0009-0006-6461-0977

Dexiang XiaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0009-0001-0669-5531

Xin LiDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China, csu.edu.cn.ORCID https://orcid.org/0000-0002-3431-226X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stress hyperglycemia ratio (SHR) is closely related to adverse clinical outcomes. However, the link between general population all-cause mortality (ACM) and cardiovascular mortality (CVM) remains undetermined. Thus, this research was designed to investigate the associations between SHR and ACM and CVM. Methods: The research data are sourced from NHANES. The correlations between SHR and death were examined via multivariate Cox proportional hazards models. These models were adjusted for clinical, socioeconomic, and demographic characteristics. Potential nonlinear relationships were estimated via restricted cubic spline (RCS) analysis. Predictive accuracy was measured by time-dependent ROC curves, and mortality risk across SHR quartiles was examined by Kaplan-Meier survival curves. Age, sex, race, BMI, level of education, smoke, and poverty-income ratio were used as subgroups to investigate potential moderators of the effect. Results: About 1847 people died from any cause and 589 from cardiovascular disease throughout the median follow-up period of 97 months. SHR was negatively associated with ACM (HR: 0.77, 95% CI: 0.68-0.88) and CVM (HR: 0.73, 95% CI: 0.60-0.90) when SHR was below the threshold values (SHR < 0.81 in ACM and SHR< 0.84 in CVM), whereas it was positively associated with ACM (HR: 1.10, 95%CI: 1.05-1.15) and CVM (HR: 1.08, 95%CI: 1.00-1.16) when it was above the threshold values. The ROC curve revealed that the SHR may serve as a predictor of ACM and CVM. Conclusions: SHR exhibits a nonlinear, threshold-dependent association with ACM and CVM, and it may serve as a predictor of ACM and CVM.

Indexed as

ACMCVMNHANESSHR

Identifiers

PMID42028289

DOI10.1155/ije/9929815

PMCPMC13101950

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