ArticleFrontiers in pediatrics2026
Immunomodulatory effects of nerve stimulator-guided brachial plexus block with laryngeal mask general anesthesia in pediatric upper limb surgery.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pediatric surgical trauma can trigger the body's stress response, leading to immune dysfunction and affecting postoperative recovery. At present, nerve stimulator-guided brachial plexus block has been widely used in children, but its effect on immune function combined with laryngeal mask general anesthesia remains to be clarified. Aim: This study assessed the impact of combined brachial plexus block and general anesthesia on inflammatory, stress, and immune responses in children undergoing upper limb surgery. Methods: This retrospective propensity score matching (PSM) cohort study analyzed children undergoing upper limb surgery (June 2022-June 2024). Participants were stratified according to the anesthesia technique used during their upper limb surgery: the observation group received nerve stimulator-guided brachial plexus block, supplemented with laryngeal mask (LMA) general anesthesia, while controls received LMA general anesthesia alone. The primary outcome was the peripheral blood T lymphocyte subsets (CD3 Results: 1:1 PSM yielded 50 matched pairs with balanced baseline characteristics (all Conclusion: Nerve stimulator-assisted brachial plexus block and LMA general anesthesia provides immunoprotection in children, enabling lower drug consumption, faster recovery, and fewer complications, thus proving clinically valuable.
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