ArticleFrontiers in pediatrics2026
Exploring reference ranges for thyroid-stimulating hormone in neonatal screening tests for preterm infants: a 5-year retrospective study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Currently, the same thyroid-stimulating hormone (TSH) cutoffs are used for term and preterm infants. Our objective was to determine TSH reference ranges and cut-off values for preterm infants born at different gestational ages (GA), birth weight (BW), and postnatal age (PNA). Methods: A retrospective analysis was performed on preterm infants who received neonatal blood screening tests (NBST) between October 2017 and December 2022. Newborns were classified based on GA, BW, and small-for-gestational-age (SGA) status. For each category, the 2.5th, 5th, 50th, 95th, and 97.5th percentiles of TSH levels were determined. The 97.5th percentile was established as the cutoff value for TSH screening. TSH reference thresholds were then established for different PNA periods. Results: Infants were categorized based on GA, BW, and SGA status. Through this categorization, it was discovered that there were disparities in the cut-off values of TSH among different groups. In particular, during the first four weeks after birth in preterm infants, the 97.5th percentile TSH level (screening cutoff), one of the key indicators in NBST, shows a sequential trend of initial decline, subsequent rise, and final decrease, which peaked at 7.38 μIU/mL in the third postnatal week. Conclusion: TSH levels in preterm infants are influenced by GA, BW, and PNA, with SGA infants showing significantly higher TSH levels (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.