ArticleBiophotonics discovery2025
Effect of skin color and other skin properties on the delivered light dose in phototherapy for neonatal hyperbilirubinemia.
Article in Biophotonics discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Significance: Hyperbilirubinemia is a common and potentially harmful condition in newborn infants. Phototherapy is the primary treatment for critically high bilirubin levels. Yet, the impact of patient skin properties and the wavelength of the phototherapy light on the delivered light dose remains unclear. Aim: We investigate the impact of patient skin properties, i.e., skin color, hemoglobin concentration, bilirubin concentration, light scattering, epidermal thickness, and subdermal tissue layer type as well as phototherapy wavelength on the delivered light dose and efficacy of phototherapy using a Monte Carlo model. Approach: The model simulates light transport through the skin to predict the delivered dose and its effect on the reduction in total serum bilirubin concentration after 24 h of treatment ( Results: Skin color, bilirubin concentration, and epidermal thickness significantly influenced the delivered light dose and predicted Conclusions: These findings highlight the need for further research into personalized phototherapy protocols to enhance treatment efficacy, particularly for hyperbilirubinemic newborn infants with darker skin.
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