Evidence map›Paper›PMID 42028244›Full record

ArticleThe World Allergy Organization journal2026

The definition of response and inadequate response to topical corticosteroid treatment in atopic dermatitis and related skin inflammatory diseases: A GA

Torsten Zuberbier, Mohamed Abuzakouk, Irena Angelova Fischer, Luisa Karla Arruda, Matthias Augustin, Lisa Beck, Jonathan Bernstein, Carsten Bindslev-Jensen, Marta Bertolín-Colilla, Christine Bangert and 75 more

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Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

85 authors.

Torsten ZuberbierInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mohamed AbuzakoukCleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Irena Angelova FischerDepartment of Dermatology, Kepler University Hospital, Linz, Austria.
Luisa Karla ArrudaRibeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Matthias AugustinUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lisa BeckDepartment of Dermatology, University of Rochester, Rochester, USA.
Jonathan BernsteinUniversity of Cincinnati, Dept of Medicine, Division of Allergy and Immunology, Cincinnati, OH, USA.
Carsten Bindslev-JensenOdense Research Center for Anaphylaxis, Odense University Hospital, Odense, Denmark.
Marta Bertolín-ColillaDermatology Department, Hospital del Mar. Hospital del Mar Research Institute, Universitat Autònoma, Universitat Pompeu Fabra, Barcelona, Spain.
Christine BangertDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Oscar Calderón-LlosaSANNA Clínica el Golf, San Isidro, Lima, Peru.
Giorgio Walter CanonicaDepartment of Biomedical Science, Humanitas University, Pieve Emanuele, Milano, Italy.
Mary Anne Roldan-CastorDivision of Allergy and Immunology Department of Pediatrics College of Medicine - Philippine General Hospital c Manila, Philippines.
Roxanne J Casis-HaoUniversity of the Philippines Manila-Philippine General Hospital Division of Allergy & Immunology, Manila, Philippines.
Ivan Cherrez-OjedaInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Karen Jui Lin ChooDepartment of Dermatology, Singapore General Hospital, Singapore.
Leena ChularojanamontriDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
Michael J CorkSheffield Children's NIHR Commercial Research Delivery Centre, Sheffield, United Kingdom.
Timothy J CraigPenn State University, Hershey, Pa, Vinmec International Hospital, Times City, Hanoi, Vietnam.
Paulo Ricardo CriadoCentro Universitário Faculdade de Medicina do ABC, Santo André, Brazil.
Adnan CustovicNational Heart and Lung Institute, Imperial College London, United Kingdom.
Tubanur ÇetinarslanManisa Celal Bayar University, Department of Dermatology and Venereology, Manisa, Turkey.
Furkan ÇalıcıoğluHealth Sciences University, Kayseri Faculty of Medicine, Kayseri City Hospital, Department of Dermatology, Urticaria & Angioedema & Atopic Dermatitis Center of Reference and Excellence Clinic, Turkey.
Marjolein de Bruin-WellerUniversity Medical Center Utrecht, the Netherlands.
Nikolaos DouladirisClinical & Molecular Allergology Center, Chalkidiki, Greece.
Luis Felipe EnsinaCPAlpha Clinical Research Center, Barueri, Brazil.
Yasemin Erdem Öztürkİstanbul University, İstanbul Faculty of Medicine, Department of Dermatology and Venereology, 34093 Çapa-İstanbul, Turkey.
Ragip ErtaşDepartment of Dermatology, Singapore General Hospital, Singapore.
Silvia Mariel FerrucciDermatology Unit. IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation of Milan, Italy.
Nelson Rosário FilhoFederal University of Parana, Brazil.
Carsten FlohrKings College London, United Kingdom.
Joachim FluhrInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Daria FominaGlobal Allergy and Asthma European Network (GA2LEN) Urticaria and Angioedema Center of Reference and Excellence (UCARE/ACARE), Moscow City Research and Clinical Center of Allergy and Immunology, City Clinical Hospital 52, Moscow Healthcare Department, Moscow, Russia.
Stamatios GregoriouNational and Kapodistrian University of Athens, 1st Department of Dermatology, Andreas Sygros Hospital, Athens, Greece.
Maia GotuaCenter of Allergy and Immunology, UCARE, ADCARE, ACARE and ANACARE Centers, Tbilisi, Georgia.
Ana Maria Giménez-ArnauDermatology Department, Hospital del Mar. Hospital del Mar Research Institute Universitat Autonoma, Universitat Pompeu Fabra, Barcelona, Spain.
Wolfram HoetzeneckerAffiliation: Department of Dermatology, Kepler University Hospital, Medical Faculty, Linz, Austria.
Carolyn JackInnovaderm Research, Montreal, Quebec, Canada.
Roberta Fachini Jardin CriadoEspiritu Santo University, Samborondon, Ecuador.
Norito KatohNorth Campus, Kyoto Prefectural University of Medicine, Japan.
Alexandros Katoulis2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, Attikon General University Hospital, Athens, Greece.
Şefika İlknur Kökçü KaradağProf.Dr.Cemil Taşcıoğlu City Hospital, Istanbul, Turkey.
Desiree Larenas-LinnemannCenter of Excellence in Asthma andnAllergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
Haur Yueh LeeSenior Consultant, Department of Dermatology, Singapore General Hospital, Singapore.
Herminio LimaMcMaster University Division of Clinic Immunology and Allergy and Division of Dermatology, Hamilton, ON, Canada.
Eli MansourAllergy and Immunology, Department of Internal Medicine, School of Medical Sciences, University of Campinas/UNICAMP, Campinas, Brazil.
Charlotte G MortzDepartment of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Mara Morelo Rocha FelixAlergolife Center, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Victor MorrisSt Luke's General Hospital Carlow/Kilkenny, Kilkenny, Ireland.
Ana Moschione CastroClinica Croce, São Paulo, SP, Brazil.
Dayanne Mota Veloso BrusckyUniversidade Federal de Pernambuco, Recife, Brazil.
Olga MukhinaMoscow Clinical Hospital 52 Research Center of Allergy and Immunology Moscow, Russia.
Dinh Van NguyenVinmec-VinUni Institute of Immunology, VinUniversity, Hanoi, Vietnam.
Audrey NosbaumHospices Civils de Lyon, Service d'Allergologie et Immunologie Clinique, 69495 Pierre Benite cedex, France.
Deniz OzcekerCPAlpha Clinical Research Center, Barueri, Brazil.
Esen ÖzkayaPenn State University, Hershey, Pa, Vinmec International Hospital, Times City, Hanoi, Vietnam.
Rabia Oztas KaraDepartment of Dermatology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Claudio A S ParisiHospital Italiano de Buenos Aires, Ciudad de Buenos Aires, Argentina.
Jonny PeterDivision of Allergy and Clinical Immunology, Groote Schuur Hospital, Department of Medicine, University of Cape Town, South Africa.
Luis PuigDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
German Dario RamonHospital Italiano Regional del Sur, Buenos Aires, Argentina.
Catalina Rincón-PérezUnidad de Especialidades Medicas, Universidad del Ejercito y Fuerza Aérea Mexicana, SEDENA, Mexico.
Umit Murat SahinerPediatric Allergy Department Hacettepe University Childrens Hospital, 06230, Ankara, Turkey.
Peter Schmid-GrendelmeierAllergiestation, Dermatologische Klinik, Universitätsspital, Zürich, Switzerland.
Esther Serra-BaldrichClinica Croce, São Paulo, SP, Brazil.
Bahar Sevimli DikicierSakarya University School of Medicine, Department of Dermatology, Sakarya Training and Research Hospital, Sakarya, Turkey.
Catherine H SmithKings College London, United Kingdom.
Petra StaubachDepartment of Dermatology University Medical Center Mainz Germany, Germany.
Katarina StevanovicInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ozlem Su KucukBezmialem Vakif University School of Medicine Dermatology Department, Adnan Menderes Bulvarı Vatan Street PK 34093 Fatih, İstanbul, Turkey.
Natasa Teovska MitrevskaRemedika General Hospital, dermatology department, Skopje, Macedonia.
Diamant ThaciInstitute and Comprehensive Center for Inflammation Medicine, University of Luebeck, Luebeck Germany.
Maria Jose TorresAllergy Unit, IBIMA-Hospital Regional Universitario de Málaga-ARADyAL, UMA, Málaga, Spain.
Tiago TorresDepartment of Dermatology, Centro Académico Clínico, ICBAS/Santo António, University of Porto, Portugal.
Maria Eduarda Trócoli ZanettiRibeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Papapit TuchindaDepartment of Biomedical Science, Humanitas University, Pieve Emanuele, Milano, Italy.
Zahava VadaszBnaiZion Medical Center, Haifa, Israel.
Efstratios VakirlisFirst Department of Dermatology-Venereology, School of Medicine, Aristotle University, Thessaloniki, Greece.
Gleison Vieira DuarteIBIS - Instituto Bahiano de Imunoterapia, Brazil.
Hannele VirtanenSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Andreas WollenbergDepartment of Dermatology and Allergy, University Hospital Augsburg, Augsburg, Germany.
Margitta WormDivision of Allergy and Immunology, Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Germany.
Yik Weng YewNational Skin Centre, Singapore.
Manuel P PereiraInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Topical corticosteroids (TCS) remain the first-line treatment for atopic dermatitis (AD) and related inflammatory skin diseases, yet no standardized definition of response exists. This gap contributes to heterogeneity in clinical practice and complicates trial design. We therefore aimed to develop consensus-based definitions of response and inadequate response to TCS therapy through a structured international eDelphi process. Methods: A PubMed search (1974-July 2025) identified 403 relevant publications. Candidate statements were drafted from the evidence and refined by the ADCARE Steering Committee, categorized into 3 domains (status quo, unmet need, proposals), and evaluated in a three-round eDelphi survey among certified ADCARE members. Eighty-four dermatologists and allergists from 32 countries participated (Round 1 response rate 98%; Round 2, 80%; Round 3, 76%). Statements were rated on a 5-point Likert scale; consensus was defined as ≥75% agreement (scores 4 or 5). Results: In total, 66 of 83 statements reached consensus. In the status quo domain, agreement centred on baseline severity, body surface area, and anatomical site as guiding factors for TCS choice, with potency and licensed duration considered central to safe prescribing. In the unmet-need domain, experts highlighted the absence of standardized definitions, variability in monitoring and escalation strategies, and gaps in long-term evidence and integration of patient-reported outcomes. In the proposal domain, consensus supported relative improvement thresholds (≥50% in EASI, SCORAD, itch NRS, IGA, PGA, POEM) and 14 days as a meaningful evaluation point. Absolute cut-offs, very short (7 days) or long (3 months) timeframes, and rigid escalation rules did not achieve consensus. These parameters were synthesized into concise and extended definitions of TCS response and inadequate response. Conclusions: This GA

Indexed as

Adrenal cortex hormonesAtopicConsensusDelphi techniqueDermatitisInflammatorySkin diseasesTopical administration

Identifiers

PMID42028244
PMCPMC13100280

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