Evidence map›Paper›PMID 42028239›Full record

ArticleTherapeutic advances in gastroenterology2026

Continuous versus intermittent anticoagulation during endoscopic treatment of esophageal varices in cirrhosis: a randomized controlled trial.

Yingying He, Zhihong Wang, Jiayi Zhang, Qianqian Zhang, Yaxian Kuai, Yuchuan Bai, Xuecan Mei, Derun Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yingying HeKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhihong WangKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Jiayi ZhangKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Qianqian ZhangKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yaxian KuaiKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yuchuan BaiKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xuecan MeiKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province 230022, China.
Derun KongKey Laboratory of Digestive Diseases of Anhui Province, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province 230022, China.ORCID https://orcid.org/0000-0002-3273-5760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endoscopic variceal treatment (EVT) in cirrhotic patients carries a risk of periprocedural bleeding, making anticoagulation management challenging in those with acute portal vein thrombosis (PVT). Objectives: The first randomized controlled trial to evaluate the safety and efficacy of continuous versus intermittent anticoagulation during EVT in cirrhotic patients with acute PVT. Methods: In this trial, cirrhotic patients with acute PVT and esophageal varices requiring EVT were assigned to either a continuous or intermittent anticoagulation group. In the continuous anticoagulation group, anticoagulation began immediately after PVT diagnosis and continued during EVT. In the intermittent group, anticoagulation was resumed 1 week post-procedurally. Incidences of post-procedural bleeding and hepatic decompensation events were observed during a 1-year follow-up period. Potential confounders were adjusted for using multivariable binary logistic regression. Results: Among 120 enrolled patients, 112 were analyzed (continuous anticoagulation group, Conclusion: Continuous anticoagulation during EVT in cirrhotic patients with acute PVT is safe and does not increase early rebleeding risk. It significantly reduces late and overall bleeding events and may improve long-term outcomes. Trial registration: Chinese Clinical Trial Registry, ChiCTR1800017430.

Indexed as

anticoagulationendoscopic treatmentesophageal varicesportal vein thrombosisrebleeding

Identifiers

PMID42028239
PMCPMC13100373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.