Evidence map›Paper›PMID 42028200›Full record

ArticleRSC advances2026

An injectable thermosensitive PLGA-PEG-PLGA hydrogel integrated with coordination-driven self-assembled MTX-Mn nanoparticles for enhanced melanoma therapy

Xiaolong Xu, Yuze Zhou, Junhao Chen, Lujing Fei, Min Qi

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaolong XuDepartment of Plastic Surgery, Xiangya Hospital, Central South University Changsha 410028 China.
Yuze ZhouDepartment of Plastic Surgery, Xiangya Hospital, Central South University Changsha 410028 China.
Junhao ChenDepartment of Dermatology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University Shenzhen 518020 China.
Lujing FeiDepartment of Plastic Surgery, Xiangya Hospital, Central South University Changsha 410028 China.
Min QiDepartment of Burns and Plastic Surgery, Shenzhen Hospital of Southern Medical University, Southern Medical University Shenzhen 518000 China qiminsmu@126.com.ORCID https://orcid.org/0009-0004-9647-0820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of malignant melanoma, an aggressive skin cancer with high recurrence and metastatic potential, often presents challenges due to systemic toxicity and multidrug resistance in current therapies. In this study, we develop a localized therapeutic platform by integrating methotrexate-manganese (MTX-Mn) coordination nanoparticles into a thermosensitive PLGA-PEG-PLGA (PPP) hydrogel to achieve sustained and site-specific drug delivery for melanoma treatment. MTX-Mn nanoparticles were synthesized through coordination-driven self-assembly and comprehensively characterized by FTIR,

Identifiers

PMID42028200
PMCPMC13101956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.