ArticleRSC advances2026
DNA origami-engineered gold nanoparticle multimers for ultrasensitive, label-free SERS detection of small molecules and biomolecules.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Surface-Enhanced Raman Spectroscopy (SERS) is a powerful vibrational spectroscopy technique capable of single-molecule sensitivity, yet its performance is critically dependent on the precise engineering of plasmonic hotspots. Conventional dimer-based substrates offer limited enhancement due to their restricted hotspot volume and intensity. Here, we overcome this limitation by leveraging the programmable addressability of DNA origami to construct a plasmonic nanofork antenna (DONA) that directs the assembly of 80 nm gold nanoparticles into well-defined multimers (trimers, tetramers, and pentamers). By systematically increasing the number of thiolated staple strands and refining the post-assembly conjugation workflow, we achieve reproducible sub-2 nm interparticle gaps, enabling dense and intense electromagnetic hotspots. This multimeric platform enables label-free SERS detection of Rhodamine 6G (R6G) down to an ultralow concentration of 10
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