ArticleBiophotonics discovery2024
Predictive model for laser-induced tissue necrosis with immunohistochemistry validation.
Article in Biophotonics discovery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Pigmentation-dependent skin injury thresholds with nanosecond single-pulse laser exposure.Journal of biomedical optics · 2026Article
- Article
- In Vivo Demonstration of Deep Learning-Based Photoacoustic Visual Servoing System.IEEE transactions on bio-medical engineering · 2026Article
- Motion-based dynamic light delivery to minimize laser-related thermal damage while preserving photoacoustic image quality.Journal of biomedical optics · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Photoacoustic imaging holds promise to provide critical guidance in surgical interventions, but its widespread use is challenged by the absence of applicable safety guidelines across diverse target tissues. The biosafety of this technology is primarily associated with the risk of necrosis generation, which is an irreversible thermal effect that can result from prolonged, high-energy laser applications. Aim: We introduce the first known numerical simulation approaches to assess laser-induced necrosis in liver tissue and present a novel microscopy analysis framework to validate performance. Approach: Our simulation methods integrate Monte Carlo simulations of laser-tissue interaction with the COMSOL interface, model local tissue heating, and predict associated tissue damage to quantify the percentage of tissue necrosis resulting from laser application. Our initial predictions are based on 30 and 73 mJ mean laser energies, laser irradiation times of 1, 10, and 20 min, and a 750 nm laser wavelength. Empirical validations with Results: Negligible tissue damage was observed with necrosis predictions Conclusions: We successfully demonstrated an
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Registered trials
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