Evidence map›Paper›PMID 42028138›Full record

ArticleJournal of intensive medicine2026

Oral acetaminophen and postoperative delirium in noncardiac surgical older patients requiring intensive care unit admission: A pragmatic randomized controlled trial.

Lina Zhang, Milin Peng, Haisong Zhang, Chengfang Xiang, Yuhang Ai, Yanyan Kong, Meijingrong Xiang, Zhaoxin Qian, Lingzhong Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lina ZhangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Milin PengDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haisong ZhangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chengfang XiangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuhang AiDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanyan KongDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Meijingrong XiangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhaoxin QianDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingzhong MengDepartment of Anesthesia, Indianapolis University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Analgesic strategies sparing opioids may reduce the incidence of postoperative delirium (POD), a grave complication affecting primarily older surgical patients. The effect of oral acetaminophen on POD in noncardiac surgical older patients requiring intensive care unit (ICU) admission is unknown. Methods: This single-center, pragmatic, open-label, parallel randomized controlled trial conducted in the ICU of Xiangya Hospital, from February 2019 to April 2021 evaluated the effect of oral acetaminophen Results: A total of 164 patients, median aged 74.8 (IQR: 62-91) years, participated in this study. POD occurred in 9 out of 82 patients (11.0%) in the acetaminophen group and 14 out of 82 patients (17.1%) in the sufentanil group. Oral acetaminophen did not lead to a reduced POD risk (risk ratio = 0.6; 95% CI: 0.3 to 1.4; Conclusions: Oral acetaminophen administered during the initial 48 h after ICU admission did not lead to a reduced incidence of POD compared with intravenous sufentanil treatments in older noncardiac surgical patients.

Indexed as

AcetaminophenAgedOperativeOralPostoperative deliriumSurgical Procedures

Identifiers

PMID42028138
PMCPMC13100874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.