Evidence map›Paper›PMID 42028114›Full record

ArticleFrontiers in neuroimaging2026

Hypereosinophilic syndrome with central nervous system involvement: a case report.

Wenjuan Xu, Chao Zhang, Fan Wang, Xiaomin Liu, Xiao Zhang, Fei Mao, Xinyi Wang, Xiaoyu Zhang

Abstract readCase Reports
In one paragraph

Article in Frontiers in neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjuan Xu *Department of General Practice, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Chao Zhang *Department of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Fan WangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Xiaomin LiuDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Xiao ZhangDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Fei MaoDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Xinyi WangDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Xiaoyu ZhangDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral infarction is the most common neurological complication in patients with hypereosinophilic syndromes (HES), typically occurring in border-zone regions. However, intracranial artery stenosis is rarely observed in HES, and the underlying mechanisms of cerebral infarction remain largely unknown. Here, we report a case of HES complicated by acute ischemic stroke secondary to severe stenosis of left middle cerebral artery (MCA). A diagnosis of idiopathic HES was established based on eosinophilia (14.08%) in bone marrow aspiration and negative genetic testing. Without contraindications, intravenous thrombolysis with alteplase was administered, resulting in a decrease of the National Institutes of Health Stroke Scale score from 13 to 2. High-resolution magnetic resonance imaging (HR-MRI) showed homogeneous, concentric wall thickening and enhancement in the terminal segments of the left internal carotid artery and at the origin of the MCA, indicating an inflammatory process. Follow-up HR-MRI at 17 months demonstrated a reduction in vessel wall enhancement after immunosuppressive therapy. Over the two-year follow-up period, the eosinophil count remained within the range of 0.22-1.09 × 10

Indexed as

case reportcerebral infarctionhypereosinophilic syndromesintracranial artery stenosisvascular wall enhancementvasculitis

Identifiers

PMID42028114
PMCPMC13099763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.