Evidence map›Paper›PMID 42028056›Full record

ArticleSAGE open medical case reports2026

Penile metastasis from prostate adenocarcinoma: A case report and review of the literature.

Angelica Cardile, Valeria Zuccalà, Vincenzo Fiorentino, Antonio Ieni, Giovanni Tuccari, Vincenzo Ficarra, Guido Fadda, Maurizio Martini, Pietro Tralongo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angelica CardileDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Valeria ZuccalàDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Vincenzo FiorentinoDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Antonio IeniDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Giovanni TuccariDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Vincenzo FicarraDepartment of Clinical and Experimental Medicine, Division of Urology, University of Messina, Italy.ORCID https://orcid.org/0000-0002-1132-1761
Guido FaddaDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Maurizio MartiniDepartment of Human Pathology of Adults and Developmental Age "Gaetano Barresi," Division of Pathology, University of Messina, Messina, Italy.
Pietro TralongoDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0003-4957-3283

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile metastasis from prostate adenocarcinoma is an exceptionally rare clinical finding, occurring in <0.3% of cases. We report an 85-year-old male with a history of Gleason 4+3 acinar adenocarcinoma, managed conservatively with long-term bicalutamide monotherapy because of his clinical stability. Eight years after diagnosis, he developed a painful, ulcerated glans lesion, surgically excised via glansectomy. Histopathology revealed solid adenocarcinoma with angiolymphatic invasion, high Ki-67 index (20-70%), PSA and CDX2 positivity, and negative CK7/CK20/TTF-1/p63 staining, confirming prostatic origin. Despite the presence of metastasis, disease progression remained indolent, supporting the feasibility of individualized, conservative therapy in selected elderly patients. Literature review highlights venous or lymphatic spread as probable pathways, with prognosis varying widely. This case underscores the importance of considering secondary malignancy in penile lesions, utilizing histopathology and immunohistochemistry for definitive diagnosis, and tailoring management to patient comorbidities and preferences to preserve quality of life.

Indexed as

conservative managementglansectomyimmunohistochemistrypenile metastasisprostate adenocarcinoma

Identifiers

PMID42028056
PMCPMC13100419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.