Evidence map›Paper›PMID 42028043›Full record

ArticleTransboundary and emerging diseases2026

Conserved Linear Epitopes in the VP1 Protein of Foot-and-Mouth Disease Virus Serotype SAT2: Identification and Characterization.

Yu-Qian Zhu, Xin-Tai Shi, Alison Burman, Zheng-Wang Shi, Tao Xi, Huan-Cheng Liao, Jun-Cong Luo, Jie Chen, Lin Wang, Ya-Ge Xie and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu-Qian ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.ORCID https://orcid.org/0009-0007-7281-4264
Xin-Tai ShiSchool of Basic Medical Sciences, Gansu Medical College, Pingliang, 744000, Gansu, China.
Alison BurmanFAO World Reference Laboratory for FMD, The Pirbright Institute, Pirbright, GU24 0NF, UK, pirbright.ac.uk.
Zheng-Wang ShiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.ORCID https://orcid.org/0000-0001-7941-8095
Tao XiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Huan-Cheng LiaoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Jun-Cong LuoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Jie ChenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.ORCID https://orcid.org/0009-0007-1548-5214
Lin WangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Ya-Ge XieState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Qian-Qian YangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.
Hong TianState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.ORCID https://orcid.org/0000-0002-1764-4916
Hai-Xue ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, lzu.edu.cn.ORCID https://orcid.org/0000-0001-6850-1379
Donald P KingFAO World Reference Laboratory for FMD, The Pirbright Institute, Pirbright, GU24 0NF, UK, pirbright.ac.uk.ORCID https://orcid.org/0000-0002-6959-2708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) serotype Southern African Territories 2 (SAT2), historically endemic to sub-Saharan Africa, has recently expanded its geographical range to the Middle East, posing a significant transboundary threat to global livestock industries. Characterized by high genetic diversity encompassing 14 distinct topotypes, SAT2 poses a challenge to reliable serological diagnosis and underscores the need for conserved, serotype-specific antigenic targets. In this study, we aimed to identify such targets by mapping linear epitopes in the VP1 capsid protein using three monoclonal antibodies (mAbs; 3B2, 6F2, and 2F11) raised against SAT2 VP1. Epitopes were mapped through sequential truncation and alanine‑scanning mutagenesis, and their conservation was assessed across VP1 sequences from 53 SAT strains (35 SAT2, 13 SAT1, and 5 SAT3). The epitope recognized by mAb 3B2 was identified as

Indexed as

Capsid ProteinsEpitopesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusAmino Acid SequenceAnimalsAntibodies, MonoclonalEpitope MappingSerogroupAntibodies, MonoclonalCapsid ProteinsEpitopesVP1 protein, Foot-and-mouth disease virusdiagnostic targetepitope conservationfoot-and-mouth disease virusSAT2VP1 linear epitope

Identifiers

PMID42028043
PMCPMC13100893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.