ArticleiScience2026
Olanzapine enhances the response of PD-(L)1 inhibitor immunotherapy: A retrospective efficacy analysis in advanced malignancies.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
This retrospective cohort study explores olanzapine's immunomodulatory role and clinical impact in patients with advanced cancer on PD-(L)1 inhibitors, given that chronic stress may impair immune checkpoint inhibitor (ICI) efficacy. Among 1933 patients with advanced cancer receiving PD-(L)1 inhibitors + chemotherapy (2018-2022), 99 received concurrent olanzapine for chemotherapy-induced nausea. After excluding 58 cases, 41 olanzapine-treated patients were propensity score-matched (PSM) for age, gender, and cancer type. Survival outcomes were analyzed via Kaplan-Meier curves and log rank tests. The olanzapine cohort showed higher objective response rate (ORR) (39.02% vs. 26.83%), comparable median PFS (9 vs. 6 months,
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