Evidence map›Paper›PMID 42027975›Full record

ArticleTanaffos2025

Evaluation of E-Cigarette Effects on Gene Expression Profile of Human Bronchial Epithelial Cells: A System Biology Approach.

Nayebali Ahmadi, Mona Zamanian Azodi, Mohammad Rostami Nejad, Mitra Rezaei, Reza Robati, Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Babak Arjmand, Mostafa Rezaei-Tavirani

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In one paragraph

Article in Tanaffos, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nayebali AhmadiProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mona Zamanian AzodiProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Rostami NejadCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mitra RezaeiClinical Tuberculosis and Epidemiology Research Center. National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza RobatiSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh BandarianEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farideh RaziDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Zahra RazzaghiLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Babak ArjmandCell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mostafa Rezaei-TaviraniProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Electronic cigarettes produce aerosols that contain flavoring agents and nicotine, a drug that can lead to dependence, which users inhale. The widespread use of e-cigarettes has prompted research projects to investigate the safety or risks of e-cigarette smoke on human health. The present study aims to discover details of the e-cigarette smoke effect on the gene expression profile of human bronchial epithelial cells (HBECs) via network analysis. Materials and Methods: Data of GSE118431(GPL16791) from Gene Expression Omnibus (GEO) were extracted and pre-evaluated by GEO2R program. The differentially expressed genes (DEGs) were analyzed via protein-protein interaction PPI analysis, and the critical DEGs were introduced. Results: A total of 192 significant DEGs among the 17058 targeted genes were selected for PPI network analysis. The 177 recognized genes were interacted to construct a network. Six DEGs were common between the hubs and bottlenecks of the network. Conclusion: E-cigarettes target IL1B, PTGS2, SOD2, NFKBIA, TXNRD1, and DUSP1, the critical genes that are associated with progression of inflammation, cell proliferation and cell invasion in cancer, chromatin condensation, DNA fragmentation, and cell death.

Indexed as

CellE-cigaretteGeneHumanNetwork

Identifiers

PMID42027975
PMCPMC13102078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.