ReviewAsian journal of pharmaceutical sciences2026
Molecular origin, discovery, validation and application of neoantigens.
Review in Asian journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Neoantigens, tumor-specific peptides originating from somatic mutations, are pivotal targets for personalized cancer immunotherapy. This review synthesizes current neoantigen research, encompassing its molecular origins, discovery methodologies, validation strategies and translational applications. We emphasize integrated genomics, mass spectrometry-based immunopeptidomics and machine learning-enhanced bioinformatics pipelines that are concurrently used to predict neoantigen processing, major histocompatibility complex (MHC)-binding affinity, and immunogenicity. Neoantigen-targeted vaccines demonstrate promising efficacy in solid tumors while combinatorial approaches integrating neoantigen-directed therapies with other immunotherapeutics show significant potential to overcome tumor immune evasion mechanisms and improve treatment outcomes. These new progresses underscore the critical role of neoantigens in advancing precision cancer immunotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.