SynthesisFrontiers in public health2026
Effects of exercise on cognitive function in older patients with Alzheimer's disease: a meta-regression and meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- The Neuroprotective Role of Exercise in Alzheimer's Disease: An Integrative Review of Animal and Human Studies.Neurology international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to systematically evaluate the effects of exercise intervention on cognitive function in AD patients through meta-analysis, specifically investigating the dose-response relationships and moderating effects of various exercise prescription parameters including frequency, single-session duration, weekly total duration, total intervention duration, type, and intensity-on the magnitude of cognitive improvement. The findings are expected to provide scientific and actionable empirical evidence for designing precise and individualized exercise programs. Methods: Relevant literatures were systematically retrieved from eight databases up to August 2025, including PubMed, Web of Science, Embase, Emcare, Scopus, Cochrane Library, Ebsco, and SPORTDiscus. All included trials were randomized controlled trials (RCTs) involving adults aged 60 years and above. These studies examined the effects of exercise intervention on cognitive function in AD patients, compared with passive control groups without exercise. A multilevel meta-analysis was used to assess the impact of exercise on cognitive function outcomes in AD patients. Additionally, multivariate meta-regression analysis was employed to identify the exercise frequency (sessions per week) that maximizes cognitive improvement, as well as key moderating factors. Results: Data from 23 studies, involving 1,868 adults, were included. Exercise intervention significantly improved global cognitive function in AD patients ( Conclusion: Exercise intervention can effectively improve cognitive function in AD patients. "To optimize intervention outcomes, exercise prescription should consider higher frequency (e.g., more than five sessions per week may be associated with greater cognitive benefits) and the cumulative effect during the initial intervention phase (e.g., sustained beyond 12 weeks may represent a critical window for short-term improvement). In addition, a potential plateau in long-term benefits suggests the need for periodic program adjustments and multimodal exercise strategies. These findings should be interpreted as exploratory dose-response associations rather than definitive clinical prescriptions. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=1012816, identifier CRD420251012816.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.