ArticleFrontiers in veterinary science2026
Case Report: Partial neurectomy and limb-sparing treatment for SOX-10 expressing epithelioid malignant nerve sheath tumour of the tibial nerve.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Epithelioid-variant malignant peripheral nerve sheath tumours (EMPNST) are rare in veterinary medicine and typically have poor outcomes. Limb-sparing partial neurectomy is used for distal peripheral nerve sheath tumours but has not previously been described for epithelioid variants. Case description: An 8.5-year-old neutered male Dobermann presented with non-weight-bearing left pelvic limb lameness and severe pain on hock flexion. CT and ultrasound showed a homogeneously thickened, contrast-enhancing segment of the left tibial nerve with muscle atrophy. Limb-sparing partial neurectomy with 2-cm margins was performed. Histopathology revealed a poorly demarcated infiltrative malignant neoplasm, completely excised. Immunohistochemistry was strongly positive for Sox-10 and negative for S-100. The dog improved rapidly, and at 12- and 24-month follow-ups showed no recurrence or metastasis. Conclusion: This case demonstrates an atypical anatomical and histopathological presentation of canine EMPNST and shows that complete limb-sparing partial neurectomy can achieve long-term remission without compromising limb function.
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