ArticleBioactive materials2026
Spatiotemporally adaptive metal-gas nanotherapy: Acid-triggered cascade release for osteoporosis treatment.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The treatment of osteoporosis remains a critical challenge due to the limitations of current therapies in simultaneously restoring homeostasis of bone metabolism and modulating the chronic inflammation of bone microenvironment. While the acidic microenvironment greatly exacerbates bone resorption, it also lays the foundation for the application of responsive therapeutic nanoplatforms. Herein, inspired by the rocket-like responsive cascade release principle-defined by a "booster-payload" mechanism, in which a metal ion-doped mesoporous silica shell serves as an early-release booster and a calcium sulfide core acts as a sustained-release payload-a bone-targeted nanoplatform (CSM
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