ArticleJOR spine2026
Detrimental Effect of Low-Magnitude High-Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment.
Article in JOR spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Introduction: Postmenopausal females are at increased risk of intervertebral disc (IVD) degeneration due to estrogen decline. While both estrogen supplementation and low-magnitude high-frequency vibration (LMHFV) are proposed as therapies for osteoporosis, their effects and potential interactions on IVD degeneration remain unclear. Therefore, the aim of this work was to investigate the individual and combined effects of 17β-oestradiol (E2) and LMHFV in a papain (PP)-induced ex vivo model of IVD degeneration. Methods: Bovine IVDs were degraded with PP (65 U/mL) and subsequently treated with E2 (10 Results: PP digestion reduced cell viability and decreased GAG content, while increasing IL-6 and MMP-3 production. Treatment with E2 partially restored Conclusion: In a severely degenerated IVD model, LMHFV promoted catabolic and inflammatory responses, and E2 treatment was insufficient to counteract these effects. These findings suggest that LMHFV, commonly used to support bone health in osteoporotic patients, may pose risks to IVD integrity in advanced degeneration.
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