Evidence map›Paper›PMID 42027792›Full record

ArticleJOR spine2026

Intradiscal

Irina Heggli, Alon Lai, Denise Iliff, Marco D Burkhard, Niklas Koehne, Harsev Singh, Jonathan J Huang, Alan C Seifert, Damien Laudier, Noah Bonnheim and 3 more

Abstract read
In one paragraph

Article in JOR spine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Irina HeggliDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0002-3064-8364
Alon LaiDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0002-0163-4588
Denise IliffDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0003-3944-4146
Marco D BurkhardDepartment of Orthopaedic Surgery Hospital for Special Surgery New York New York USA.ORCID https://orcid.org/0000-0003-1501-1952
Niklas KoehneDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0009-0007-8542-1363
Harsev SinghDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0009-0006-6875-1590
Jonathan J HuangDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0009-0003-5863-089X
Alan C SeifertBiomedical Engineering and Imaging Institute, Department of Radiology Icahn School of Medicine at Mount Sinai, Leon and Norma Hess Center for Science and Medicine New York New York USA.ORCID https://orcid.org/0000-0001-7877-4813
Damien LaudierDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0003-4674-7460
Noah BonnheimDepartment of Orthopaedic Surgery Atrium Health Musculoskeletal Institute, Wake Forest University School of Medicine Charlotte North Carolina USA.ORCID https://orcid.org/0000-0003-2191-180X
Levon RodriguezDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0003-3023-2489
Timothy D JacobsenDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0001-8944-8095
James C IatridisDepartment of Orthopedics Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0002-2186-0590

Funding

Mechanisms for Regenerative Healing in Intervertebral DiscsR01AR080096 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI James C. Iatridis · 2022 to 2026
$3.8M
Role of TNFalpha in discogenic pain progression and as a treatment targetR01AR078857 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI James C. Iatridis · 2022 to 2026
$3.2M
NIAMS NIH HHS R01 AR078857NIAMS NIH HHS R01 AR080096
6 · The paper itself

Abstract

Background: Modic changes (MC) are painful vertebral bone marrow lesions. Three interconvertible types represent different pathology stages with MC1 being the most painful, MC2 less painful, and MC3 asymptomatic. Bacterial ( Aims: To assess MC-subtype lesion prevalence and pain-like behavior over time in an etiology-specific MC rat model. Methods: Four-to-five-month-old Sprague-Dawley rats underwent sham ( Results: Conclusion: Intradiscal

Indexed as

Cutibacterium acnes (C. Acnes)intervertebral disc degenerationlumbar endplate injury rat modelMC etiologyModic change (MC) conversion

Identifiers

PMID42027792
PMCPMC13102498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.