ArticleFrontiers in oral health2026
A novel approach for the management of infrabony periodontal defects using autologous dentin and L-PRF: a clinical case series report.
Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Autologous dentin has emerged as a biologically active alternative to xenogeneic grafts, yet its clinical application in periodontal healing remains limited. Leukocyte- and platelet-rich fibrin (L-PRF) provides a scaffold that releases biomolecules to enhance wound healing. This case series evaluates the clinical and radiographic outcomes of a fully autologous L-PRF dentin block for the treatment of infrabony periodontal defects. Methods: Six patients presenting with twenty infrabony defects were treated with an L-PRF dentin block graft composed of particulate autologous dentin combined with L-PRF membranes and liquid fibrinogen. At baseline and after 6 months, Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were evaluated clinically, and defect dimensions were assessed by Cone-beam computed tomography (CBCT). Pain was evaluated using a visual analog scale at 0, 7, 14, and 21 days. Results: Significant improvements were observed in all clinical parameters at 6 months: CAL decreased from 5.7 mm (95% CI: 5.1-6.2) to 1.6 mm (95% CI: 0.8-2.4; Conclusion: The L-PRF dentin block represents a promising, fully autologous, biologically based approach for the treatment of infrabony periodontal defects, associated with favorable preliminary clinical and radiographic outcomes with minimal postoperative discomfort. These findings suggest that this approach may represent a feasible and biologically compatible alternative to conventional graft materials. However, randomized clinical trials are needed to confirm these preliminary findings.
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