ArticleJournal of oral biology and craniofacial research
Regenerative potential of MSC-derived secretomes in radiation-induced xerostomia: Role of SDF-1, IL-10, and VEGF.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aims to analyze the potential of MSC-derived secretomes, specifically SDF-1, IL-10, and VEGF, as an alternative therapy for xerostomia or other disorders caused by ionizing radiation. Materials and methods: This research is an experimental laboratory-based analytical study. The samples were secretomes derived from mesenchymal stem cells (MSCs) isolated from human umbilical cords. The MSCs were divided into two groups: the control group (K), which consisted of MSC cultures without X-ray exposure, and the treatment group (P), consisting of MSC cultures exposed to X-rays. Each cell culture was incubated until day 3 and day 7. The secretion levels of SDF-1, IL-10, and VEGF were then measured using a sandwich ELISA test. Results: The study showed that the average secretion levels of SDF-1, IL-10, and VEGF increased significantly after exposure to 0.16 mSv ionizing radiation, both on day 3 and day 7, compared to the control group without radiation exposure. However, the average secretion levels of SDF-1, IL-10, and VEGF in the treatment group on day 7 (P.7) were lower than those on day 3 (P.3). Conclusion: Secretomes from MSC cultures have great potential as an alternative therapy for xerostomia or other disorders caused by ionizing radiation, serving as a cell-free therapy. Secretomes contain various bioactive molecules such as cytokines, chemokines, antioxidants, and growth factors that play a crucial role in cell and tissue regeneration.
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