ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
Vitamin D Metabolite Ratios and Association with Type 2 Diabetes Mellitus in a Youth Saudi Population.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Vitamin D deficiency is highly prevalent in Saudi Arabia and has been associated with type 2 diabetes mellitus (T2DM). The vitamin D metabolite ratio (VMR), defined as the ratio of 24,25-dihydroxyvitamin D Patients and Methods: A cross-sectional study was conducted involving 971 Saudi adolescents (age 14.9 ± 1.7 years), including 864 normoglycemic individuals, 74 with prediabetes, and 33 with T2DM. Serum vitamin D metabolites [25(OH)D Results: Lower VMR (<4%) was associated with higher odds of T2DM (OR: 4.7, 95% CI: 1.1-20.0, p = 0.036), though the wide confidence interval reflects the small T2DM sample size (n=33). Preliminary analysis indicated that VMR may be associated with T2DM in Saudi adolescents, but findings should be interpreted cautiously given the small T2DM sample and cross-sectional design. Larger prospective studies are needed to confirm these preliminary observations. Conclusion: A lower vitamin D metabolite ratio is associated with T2DM among Saudi adolescents. VMR may provide complementary information beyond total 25(OH)D; however, formal comparative predictive analyses were not performed, underscoring the importance of proper vitamin D metabolism in glucose homeostasis. However, given the cross-sectional design and small T2DM sample size, these findings are preliminary and require validation in larger prospective studies.
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