Evidence map›Paper›PMID 42027665›Full record

ArticleF&S reports2026

Embryonic origin of XX/XY chimerism in an in vitro fertilization-conceived individual.

Anjali Patel, Ecem Esencan, Zameena Lakhani, Eve C Feinberg

Abstract readCase Reports
In one paragraph

Article in F&S reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anjali PatelNorthwestern Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Ecem EsencanDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Zameena LakhaniDepartment of Obstetrics and Gynecology, Division of Clinical Genetics, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Eve C FeinbergDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To report an adult case of XX/XY chimera resulting from in vitro fertilization with transfer of three embryos, that was discovered with preconception genetic carrier screening. Design: Case report. Subject: A 33-year-old nulliparous woman who was conceived via in vitro fertilization with three embryos transferred presented for embryo banking for future family building. Exposure: Genetic carrier screening panel. Main Outcome Measures: Genomic analysis of recessive gene carrier status. Results: An inconclusive genetic carrier screening result led to further investigation that revealed two distinct cell lines, one containing Y-chromosome material, confirming the diagnosis of chimerism. Conclusion: There may be an undiagnosed population of human chimeras resulting from the transfer of multiple embryos with assisted reproductive technologies. The biologic and clinical implications of congenital chimerism are incompletely understood.

Indexed as

Chimeraembryo transfergenetic counselingin vitro fertilization

Identifiers

PMID42027665
PMCPMC13100861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.