Evidence map›Paper›PMID 42027651›Full record

ArticleOpen forum infectious diseases2026

Epidemiology and Clinical Features of Cryptococcosis Among Individuals Without HIV Infection: An Observational International Multicenter Study (MSG-11).

Yee-Chun Chen, Sharon C A Chen, Gerald McGwin, Arunaloke Chakrabarti, Oliver A Cornely, Aleksandra Barac, Harsimran Kaur, Shivaprakash M Rudramurthy, Peter Phillips, Carlos Seas and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yee-Chun ChenDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-1816-9010
Sharon C A ChenCenter for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9983-6603
Gerald McGwinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Arunaloke ChakrabartiDoodhadhari Burfani Hospital & Research Institute, Bhupatwala, Haridwar, Uttarakhand, India.ORCID https://orcid.org/0000-0003-1555-3807
Oliver A CornelyCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, and Excellence Center for Medical Mycology (ECMM), Division of Infectious Diseases, Department I of Internal Medicine, Institute of Translational Research, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0001-9599-3137
Aleksandra BaracClinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-0132-2277
Harsimran KaurDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.ORCID https://orcid.org/0000-0002-4871-8113
Shivaprakash M RudramurthyDepartment of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Peter PhillipsDivision of Infectious Diseases, St Paul's Hospital and the University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-0336-1966
Carlos SeasInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, and Hospital Cayetano Heredia, Lima, Peru.ORCID https://orcid.org/0000-0001-7067-9141
Rachel McMullenMycoses Study Group Central Unit, Department of Internal Medicine, Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Peter G PappasMycoses Study Group Central Unit, Department of Internal Medicine, Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-3643-9931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infections due to Methodology: This prospective, observational, multinational study enrolled HIV-uninfected patients with proven/probable cryptococcosis from 7 countries on 4 continents located in temperate, subtropical and tropical zones. Patients were identified based on culture, histopathology and/or serologic testing. Relevant clinical and epidemiologic data were collected. Results: We identified 103 subjects with proven and probable cryptococcosis. Mean age was 53.8 years and 72% were male. Predisposing conditions were present in 70 patients (68%); most commonly malignancy, non-transplant related immunosuppressive therapy, and solid organ transplantation. Median time to diagnosis in non-immunocompromised individuals was 67 days compared to 19.7, 31.3 and 61 days for organ transplant, hematologic malignancy and other conditions, respectively. Survival at 3 and 12 months was similar across all risk groups. Conclusions: Epidemiology, time to diagnosis, treatment and outcomes for HIV-uninfected persons with cryptococcosis in very diverse geographic regions are similar to data from North America and Western Europe.

Indexed as

cryptococcosiscryptococcus gattiicryptococcus neoformansnon-HIV infected individuals

Identifiers

PMID42027651
PMCPMC13102100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.