Evidence map›Paper›PMID 42027518›Full record

ArticleAnnals of thoracic surgery short reports2026

Thoracic Duct-to-Azygous Vein Lymphovenous Anastomosis for Lymphatic Decompression: Initial Experience and Early Outcomes.

Benjamin Smood, Katsuhide Maeda, Rosa Hwang, Dalal Taha, Yoav Dori, Christopher Smith, Pablo Laje

Abstract read
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Article in Annals of thoracic surgery short reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Benjamin SmoodDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Katsuhide MaedaDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Rosa HwangDivision of General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Dalal TahaNeonatology Division, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Yoav DoriCenter for Lymphatic Disorders, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Christopher SmithCenter for Lymphatic Disorders, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pablo LajeCenter for Lymphatic Disorders, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thoracic duct obstruction can cause devastating lymphatic complications, and definitive treatments remain lacking. This investigation evaluated our initial experience and early outcomes using a surgically created thoracic duct-to-azygous vein lymphovenous anastomosis (TDA-LVA) to provide lymphatic decompression in critically ill neonates and infants with thoracic duct obstruction. Methods: All children who underwent TDA-LVA creation at the Children's Hospital of Philadelphia between December 2019 and January 2024 were retrospectively reviewed. Preoperative and postoperative clinical characteristics were compared among all patients. Primary end points of analysis included survival to discharge and at last follow-up. Results: Eight children (median weight, 4.5 kg; interquartile range [IQR], 3.5-5.0 kg) underwent successful TDA-LVA creation. All procedures were tolerated very well. One patient (1 of 8 [12.5%]) required chest washout on postoperative day (POD) 7, and 1 TDA-LVA was unsuccessfully revised on POD 21. The median hospital length of stay after TDA-LVA creation was 138 days (IQR, 64-241 days). Overall, 6 of 8 patients (75.0%) survived to hospital discharge, all of which (6 of 6 [100.0%]) remained alive at a median follow-up of 165 days (IQR, 18-521 days) after discharge. Postoperative TDA-LVA patency was confirmed with conventional lymphangiography in 5 of 8 patients (62.5%), and up to POD 70. Conclusions: A TDA-LVA can restore lymphatic fluid drainage into the systemic venous circulation and remain patent for >2 months in carefully selected patients with thoracic duct obstruction. Further investigations are needed to determine the long-term durability and potential impact on overall quality of life and survival in children with complex lymphatic disorders.

Identifiers

PMID42027518
PMCPMC13100813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.