Evidence map›Paper›PMID 42027468›Full record

ArticleOphthalmology science2026

Retinal Blood Flow Decreases After Treatment with Laser Photocoagulation for Retinopathy of Prematurity.

Shaiza Mansoor, Christina Kilby, Joyce Wang, Jeong-Yoon Wu, He Eun Forbes, Jason Zhou, Ria Kapoor, Urjita Das, Sarah Ward, Hansine Vexlund and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shaiza MansoorSchool of Medicine, University of Maryland, Baltimore, Maryland.
Christina KilbyDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Joyce WangSchool of Medicine, University of Maryland, Baltimore, Maryland.
Jeong-Yoon WuDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
He Eun ForbesDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Jason ZhouSchool of Medicine, University of Maryland, Baltimore, Maryland.
Ria KapoorDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Urjita DasDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Sarah WardDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Hansine VexlundDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Kristin WilliamsDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Moran Roni LevinDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.
Sripriya SundararajanDivision of Neonatology, Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, Maryland.
Larry MagderSchool of Public Health, University of Maryland, Baltimore, Maryland.
Avigyan SinhaVasoptic Medical, Inc, Columbia, Maryland.
Abhishek RegeVasoptic Medical, Inc, Columbia, Maryland.
Janet Leath AlexanderDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.

Funding

Identification of Anterior Segment Structural Biomarkers in Glaucoma Following Pediatric Cataract Using Ultrasound BiomicroscopyK23EY032525 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER, JANET LEATH · 2022 to 2024
$709k
Development of Flow Based Biomarkers for Retinopathy of Prematurity - Supplemental AimR43EY030798 · NEI · VASOPTIC MEDICAL, INC. · PI REGE, ABHISHEK · 2019 to 2020
$389k
NEI NIH HHS K23 EY032525NEI NIH HHS R43 EY030798
6 · The paper itself

Abstract

Purpose: To compare total retinal blood flow (TRBF) rates before and after retinopathy of prematurity (ROP) treatment with laser photocoagulation using laser speckle contrast imaging (LSCI). Design: Prospective cohort study. Participants: Fourteen eyes from 8 premature infants in the neonatal intensive care unit receiving laser photocoagulation treatment for ROP. Methods: Total retinal blood flow was measured using LSCI longitudinally before and after laser treatment. Subject characteristics and clinical ROP features were included in regression analysis using generalized estimating equations to account for 2 eyes per subject and longitudinal measures over time. Main Outcome Measures: The main outcome measure was peak TRBF. Results: Prior to ROP treatment with laser photocoagulation, subjects had a peak TRBF of 8.8 ± 2.1 a.u. compared to 7.3 ± 1.4 a.u. after treatment (mean difference = 1.5 a.u., Conclusions: We observed lower TRBF after ROP treatment with laser photocoagulation. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Anti-VEGFLaser photocoagulationLaser speckle contrast imagingRetinopathy of prematurityTotal retinal blood flow (TRBF)

Identifiers

PMID42027468
PMCPMC13099490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.