Evidence map›Paper›PMID 42027410›Full record

ArticleCrohn's & colitis 3602026

Incidence and prevalence of immune-mediated extraintestinal manifestations in pediatric inflammatory bowel disease: a systematic review and meta-analysis.

Ruben J Colman, Sudheer K Vuyyuru, Virginia Solitano, John K MacDonald, Jessica Le, Amanda Ricciuto, Roberta Berard, Javed A Mohammed, Christopher Ma, Vipul Jairath and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Crohn's & colitis 360, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruben J ColmanDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stanford University School of Medicine, Stanford, CA, United States.ORCID https://orcid.org/0000-0001-9891-8570
Sudheer K VuyyuruDepartment of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University, London, ON, Canada.
Virginia SolitanoDivision of Gastroenterology and Gastrointestinal Endoscopy, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-2935-6778
John K MacDonaldAlimentiv Inc., London, ON, Canada.
Jessica LeAlimentiv Inc., London, ON, Canada.
Amanda RicciutoDivision of Gastroenterology, Hepatology and Nutrition, SickKids Inflammatory Bowel Disease Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Roberta BerardDepartment of Pediatrics, Division of Rheumatology, London Health Sciences Center, London, ON, Canada.ORCID https://orcid.org/0000-0003-2780-0617
Javed A MohammedPediatric Dermatology, Department of Pediatrics, Children's Hospital, London Health Sciences Center, London, ON, Canada.
Christopher MaAlimentiv Inc., London, ON, Canada.ORCID https://orcid.org/0000-0002-4698-9948
Vipul JairathDepartment of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0002-1092-0033
Eileen CrowleyAlimentiv Inc., London, ON, Canada.ORCID https://orcid.org/0000-0002-9545-4384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Immune-mediated extraintestinal manifestations (IM-EIMs) are common in pediatric inflammatory bowel disease (pIBD). This systematic review and meta-analysis aimed to summarize the incidence and prevalence of IM-EIMs in pIBD. Methods: MEDLINE, EMBASE, CENTRAL, and clinicaltrials.gov were searched up to May 6, 2024, for studies that included pIBD (2-17 years) patients diagnosed with IM-EIMs. Primary outcomes included the incidence and prevalence of IM-EIMs among pIBD. Meta-analysis included pooled proportions of IM-EIMs using DerSimonian-Laird random-effects model. Results: The pooled proportion of IM-EIMs overall was 10% (95% CI, 8%-12%; I Conclusions: While musculoskeletal manifestations are common, fewer than 5% of pIBD patients experience ophthalmological, dermatological, and liver IM-EIMs. The small number of studies resulted in significant methodological and statistical heterogeneity. Multicenter collaborative efforts are needed to systematically describe the epidemiology of IM-EIMs in pIBD.

Indexed as

immune-mediated extraintestinal manifestationsincidencepediatric inflammatory bowel diseaseprevalence

Identifiers

PMID42027410
PMCPMC13099386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.