ArticleResearch and practice in thrombosis and haemostasis2026
Diagnostic accuracy of Clauss and prothrombin time-derived fibrinogen against rotational thromboelastometry FIBTEM-A5.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fibrinogen levels may fall early in major hemorrhage. The Clauss assay (Fib-C) is the laboratory gold standard, while the prothrombin time-derived assay (Fib-D) is a rapid, lower-cost alternative. Objectives: To compare Fib-C and Fib-D with viscoelastic-derived clot firmness. Methods: Data from all Queensland Health hospitals were extracted (2019-2025). Rotational Thromboelastometry FIBTEM-A5 was the reference standard. Paired Fib-C and Fib-D results with FIBTEM-A5 were analyzed. The primary outcome was correlation with FIBTEM-A5; secondary analyses assessed predictive performance for FIBTEM-A5 of ≤ 10 mm. Results: Of 2208 paired results were included, Fib-C correlated more strongly with FIBTEM-A5 than Fib-D ( Conclusion: Fib-C aligns more closely with viscoelastic clot firmness than Fib-D. These results support Fib-C as the preferred assay and discontinuing routine Fib-D reporting in critical bleeding.
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