ReviewResearch and practice in thrombosis and haemostasis2026
Platelet effector functions in inflammation.
Review in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Platelets Enter the Itch Circuit.Research (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A State of the Art lecture titled "Platelet effector functions in inflammation" was presented at the International Society on Thrombosis and Haemostasis congress in 2025. It is increasingly recognized that platelets are critical orchestrators of innate and adaptive immune responses. In this review, we highlighted how these cells partially engage distinct receptors, signaling pathways, and effector functions to fulfill their role in immunity. In the inflamed microenvironment, platelets migrate along substrate gradients to optimize positioning to sites of injury or pathogen entry in an actin-related protein 2/3 complex-dependent manner. This allows for pathogen collection and bundling, as well as prevention of inflammatory bleeding. For the latter task, platelets integrate activation signals via glycoprotein VI and integrin αIIbβ3 to undergo procoagulant transformation, triggering local and restricted coagulation. We provided an overview of how these mechanisms are also associated with hyperinflammation and immunopathology, and how procoagulant activity is a driver of arterial and venous thrombosis. Moreover, we discussed that platelets increase their propensity for immune engagement over their lifespan while losing hemostatic prowess. Finally, we summarized additional relevant new data on this topic presented during the 2025 International Society on Thrombosis and Haemostasis Congress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.