ArticleResearch and practice in thrombosis and haemostasis2026
Impaired thrombin generation as a reproducible feature of bleeding disorder of unknown cause.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thrombin generation (TG) has previously been investigated in patients with bleeding disorder of unknown cause (BDUC) with discrepant results. Objective: To investigate whether previously reported impairments of TG in BDUC patients can be resproduced using a automated TG analysed at different tissue factor concentrations. Methods: In this case-control cohort study, TG was measured in patients with BDUC and age- and sex-matched healthy controls using the fully automated Ceveron S100 assay with 2 trigger reagents: reagent B (RB; very low tissue factor concentration) and reagent C-low (RC; low tissue factor concentration). Results: In total, 62 patients and 22 controls were analyzed. In both reagents, patients compared with healthy controls had longer time to peak (RB: 16.2 vs 12.8 seconds; RC-low: 10.3 vs 8.5 seconds; Conclusion: This study highlights the reproducibility of impaired TG in patients with BDUC. Given that BDUC pathophysiology remains largely unknown, these findings suggest impaired TG may represent a common underlying feature of BDUC and underscore the need for further validation in independent cohorts and clinical settings.
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