ArticleMedical physics2026
A preclinical setup for spatially fractionated radiation therapy with electrons.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSpatially fractionated radiation therapy (SFRT) has therapeutic potential as a priming therapy which boosts tumor control. However, the optimal delivery and spatial fractionation parameters have not been deciphered and the mechanisms at play are not yet fully understood. PURPOSE: This paper highlights our preclinical setups for mini-grid SFRT with 6 MeV electrons delivered at conventional to ultrahigh dose rates, using a flexible collimator system. These setups let us explore relevant spatial fractionation parameters to observe their effect on tumor growth and normal tissue toxicity. Preclinical studies here may reveal the parameters of highest clinical relevance for SFRT and combination therapies.
methodsFor preclinical experiments with electron spatial fractionation, 6.5 mm thick brass collimators were made with 7- (or 19-) hole hexagonally packed ∅ 0.65-2 mm apertures, with 1.6-5 mm CTC distances. Irradiated EBT-XD Gafchromic film downstream of collimators were analyzed to obtain peak-to-valley dose ratios (PVDR), full width at half maxima (FWHM), and peak doses at various depths in solid water, and at surface when increasing the separations from collimators in air. Male and female C57BL/6 mice were injected subcutaneously with UPPL1541 bladder cancer cells in the right flank. After 10-13 days, a single dose treatment was delivered to the tumors with either ∅14 mm circular homogeneous field (10 Gy delivered at 3 kGy s
resultsSimilar PVDRs were obtained with 7- and 19-hole inserts (35 and 31 at surface, respectively). Peak widths increased with depth, and maximal peak dose rates were > 1.8 kGy s
conclusionsSpatially fractionated electron FLASH treatments with 30 Gy peak doses and 2.1 Gy valley doses provide effective tumor growth delay and prolonged tumor control akin to 10 Gy homogeneous irradiations. Here we demonstrate that combining spatial modulation, higher peak doses, and FLASH dose rates can produce favorable tumor response.
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