Evidence map›Paper›PMID 42027125›Full record

ArticleBJPsych open2026

Prevalence and determinants of anxiety in amyotrophic lateral sclerosis.

Edoardo Nicolò Aiello, Giulia De Luca, Beatrice Curti, Silvia Torre, Claudia Gendarini, Alessandro Cocuzza, Eleonora Colombo, Angelica De Sandi, Denise Mellace, Roberta Ferrucci and 9 more

Abstract read
In one paragraph

Article in BJPsych open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Edoardo Nicolò AielloDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Giulia De LucaDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Beatrice CurtiDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Silvia TorreDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Claudia GendariniNeurology Residency Programme, Università degli Studi di Milano, Milano, Italy.
Alessandro CocuzzaNeurology Residency Programme, Università degli Studi di Milano, Milano, Italy.
Eleonora ColomboDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Angelica De SandiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Denise MellaceDepartment of Oncology and Haemato-Oncology, Università degli Studi di Milano, Milano, Italy.
Roberta FerrucciFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Sergio BarbieriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Alessio MaranzanoDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Federico VerdeDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Stefano MessinaDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Alberto DorettiDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Claudia MorelliDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Vincenzo SilaniDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Nicola TicozziDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.
Barbara PolettiDepartment of Neurology and Laboratory of Neuroscience, https://ror.org/033qpss18IRCCS Istituto Auxologico Italiano, Milano, Italy.ORCID https://orcid.org/0000-0003-4398-2051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinically relevant anxiety can be detected in patients with amyotrophic lateral sclerosis (ALS), but its prevalence and determinants have not yet been fully assessed.

aimsThis study aimed at assessing the prevalence and clinical underpinnings of anxiety in ALS.

methodNon-demented ALS patients (

resultsSTAI-Y1 and -Y2 scores above cut-off were detected in 18.2 and 13.9% of patients, respectively - with proportions being higher in cases versus controls (

conclusionsClinically significant levels of state- and trait-anxiety occur in ∼18 and ∼14% of non-demented ALS patients, respectively, mostly driven by cognitive and affective facets of depression, and are independent of motor and cognitive/behavioural features.

Indexed as

Amyotrophic lateral sclerosisanxietydepressionpsychiatry

Identifiers

PMID42027125
PMCPMC13122346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.