Tabernaemontana catharinensis: A Source of Indole Alkaloids With Potential Activity as Chemotherapeutic Agents.

Ana Júlia Gomes Donada, Rafael Freitas Corá, Bianca Canci, Mariana Roesch-Ely, Pauline Fagundes Rosales, Sidnei Moura

Abstract read

In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana Júlia Gomes DonadaLBIOP-Laboratory of Biotechnology of Natural and Synthetic Products, Technology Department, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.

Rafael Freitas CoráLBIOP-Laboratory of Biotechnology of Natural and Synthetic Products, Technology Department, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.

Bianca CanciLaboratory of Applied Toxicology and Bioproducts, University of Caxias do Sul, Caxias do Sul, Brazil.

Mariana Roesch-ElyLaboratory of Applied Toxicology and Bioproducts, University of Caxias do Sul, Caxias do Sul, Brazil.

Pauline Fagundes RosalesIFRS-Federal Institute of Education, Science and Technology of Rio Grande Do Sul, Campus Bento Gonçalves, Brazil.

Sidnei MouraLBIOP-Laboratory of Biotechnology of Natural and Synthetic Products, Technology Department, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, Brazil.ORCID https://orcid.org/0000-0003-1903-6735

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (Edital Universal - 2025)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES), CNPq, and FPERGSCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESFundação de Amparo a Pesquisa do Estado do Rio Grande do Sul - FAPERGS (Edital 09/2023 Programa Pesquisador Gaúcho - PQG, Termo De Outorga: 24/2551-0001302-4)

6 · The paper itself

Abstract

This study aimed to evaluate the antitumor activity of fractions rich in indole alkaloids extracted from the leaves of the species Tabernaemontana catharinensis. The chemical composition was analyzed using high-resolution mass spectrometry (HRMS), which identified nine known indole alkaloids, including voacangine, voacangine hydroxyindolenine, ibogamine, and affinisine. In the subsequent step, both the extract and the fractions were tested against the human colorectal carcinoma cell line HCT116. Cytotoxicity assays showed that the total alkaloid fraction (AF) exhibited selectivity against this tumor cell line (IC

Indexed as

Antineoplastic Agents, PhytogenicIndole AlkaloidsTabernaemontanaAnimalsArtemiaCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHumansMolecular StructurePlant ExtractsPlant LeavesStructure-Activity RelationshipAntineoplastic Agents, PhytogenicIndole AlkaloidsPlant Extractscolorectal carcinomaHCT116 cellindole alkaloidsTabernaemontana catharinensis

Identifiers

PMID42026976

DOI10.1002/cbdv.202503532

PMCPMC13107091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.