Elevated gamma-glutamyl transferase levels in early pregnancy increase pregnant women's risk of gestational hypertension and preeclampsia.

Chuanlu Xu, Yuping Tang, Yirong Bao, Yuhong Li, Jia Zuo, Xiaohua Liu, Xiaoxian Qu, Hao Ying

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Article in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Chuanlu Xu *Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Yuping Tang *Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Yirong BaoDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Yuhong LiDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Jia ZuoDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Xiaohua LiuDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Xiaoxian QuDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Hao YingDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

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6 · The paper itself

Abstract

Background: The association between liver dysfunction in early pregnancy and the hypertensive disorders in pregnancy (HDP) remains unclear. Methods: This retrospective cohort study included all singleton pregnant women (n = 57 386) who underwent liver function tests (LFTs) at their first antenatal visit from six to 19 Results: Among the 50 423 women included in the study, 17.1% had abnormal liver function. The overall HDP rate was 3.9%. Across the different serum Gamma-glutamyltransferase (GGT)groups, the HDP incidence rates were 2.9% (0-12 units per litre /U/L)), 5.4% (12.1-32 U/L), 10.0% (32.1-64 U/L), and 10.5% (>64 U/L) (P < 0.001 for trend). Compared with the reference range for GGT (0-12 U/L), the group with GGT levels of 12.1-32 U/L exhibited a 48.6% greater risk (adjusted odds ratio (OR) = 1.486; 95% confidence interval (CI) = 1.344-1.642), the group with GGT levels of 32.1-64 U/L had a 50.9% increased risk (aOR = 1.509; 95% CI = 1.375-1.657), and those with GGT levels >64 U/L had a 25.0% greater risk (aOR = 1.250; 95% CI = 1.078-1.449) of HDP. We further assessed the associations between varying GGT levels and HDP subtypes (gestational hypertension, mild PE, severe PE, early onset PE, and late-onset PE), and similar results were obtained for all subtypes. Restricted cubic spline (RCS) curves revealed that elevated serum GGT levels have a dose-response relationship with HDP, along with its subtypes. Conclusions: GGT levels during early pregnancy have a dose-response relationship with the development of HDP and its subtypes.

Indexed as

gamma-GlutamyltransferaseHypertension, Pregnancy-InducedPre-EclampsiaAdultBiomarkersFemaleHumansLiver Function TestsPregnancyRetrospective StudiesRisk FactorsBiomarkersgamma-Glutamyltransferase

Identifiers

PMID42026955

DOI10.7189/jogh.16.04132

PMCPMC13107083

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