Evidence map›Paper›PMID 42026881›Full record

ArticleBrain, behavior, and immunity2026

The role of lymphocytic CD5 in the effects of ethanol on mesolimbic circuitry and ethanol consumption behavior.

A J Payne, J D Obray, B M Williams, R J Campbell, L H Ford, J W Ronström, C A Nelson, J D G Murcia, C M T Freitas, C J Chapman and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

A J PayneDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States; Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, United States. Electronic address: AJPayne@NoordaCOM.org.
J D ObrayDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.
B M WilliamsDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.
R J CampbellDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States.
L H FordDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States.
J W RonströmDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States.
C A NelsonDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.
J D G MurciaDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, United States.
C M T FreitasDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, United States.
C J ChapmanDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.
J K BaldridgeDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.
Z J Boyce JoyDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States.
C M MorenoDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, United States.
J G EdwardsDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States.
K S WeberDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, United States.
J T YorgasonDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, United States; Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.
S C SteffensenDepartment of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, United States.

Funding

Nicotine and Alcohol Co-DependenceR01DA035958 · NIDA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2014 to 2018
$2.0M
Neuroplasticity with alcohol dependenceR01AA020919 · NIAAA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2012 to 2016
$1.5M
Neuroimmune mechanisms of alcohol rewardR01AA030577 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jordan Thomas Yorgason · 2023 to 2026
$1.3M
Ventral Tegmental Area GABA Neurons: Plasticity & Opiate Receptors at InhibitoryInputsR15DA049260 · NIDA · BRIGHAM YOUNG UNIVERSITY · PI EDWARDS, JEFFREY G · 2020 to 2024
$905k
Amelioration of opioid withdrawal-induced anxiety and craving with heterodyned whole body vibrationR41DA053083 · NIDA · PHOTOPHARMICS, INC. · PI ADAMS, DANIEL NATHAN, STEFFENSEN, SCOTT C · 2021 to 2021
$320k
Amelioration of opioid use disorder with heterodyned whole body vibrationR42DA060644 · NIDA · PHOTOPHARMICS, INC. · PI ADAMS, DANIEL NATHAN, STEFFENSEN, SCOTT C · 2024 to 2024
$319k
NIAAA NIH HHS R01 AA020919NIAAA NIH HHS R01 AA030577NIDA NIH HHS R01 DA035958NIDA NIH HHS R15 DA049260NIDA NIH HHS R41 DA053083NIDA NIH HHS R42 DA060644
6 · The paper itself

Abstract

Cluster of differentiation 5 (CD5) is a negative regulatory molecule that alters lymphocyte activation pathways and is expressed on the surface of T cells, a subset of B cells (B1 cells), and dendritic cells. CD5 expression is sensitive to ethanol (EtOH) exposure, as the number of CD5

Indexed as

Alcohol DrinkingCD5 AntigensEthanolMesolimbic SystemAnimalsCocaineDopamineFemaleGABAergic NeuronsMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, GABA-AVentral Tegmental AreaCD5 AntigensCocaineDopamineEthanolReceptors, GABA-AAlcoholAlcohol behaviorCD5Chronic ethanol useEthanol consumptionNeuroimmune

Identifiers

PMID42026881
PMCPMC13078736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.