Evidence map›Paper›PMID 42026729›Full record

ArticleArtificial organs2026

Validation of Aortic Blood Flow Simulations During Extracorporeal Circulation Using Phase Contrast Magnetic Resonance Imaging.

Anna Kathrin Assmann, Sinje Reimers, Jonah S Schrauder, Lei Qu, Xiangge Yin, Amir Moussavi, Artur Lichtenberg, Susann Boretius, Michael Neidlin, Alexander Assmann

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna Kathrin AssmannDepartment of Cardiac Surgery, Heinrich-Heine-University, Düsseldorf, Germany.ORCID https://orcid.org/0000-0002-9025-8640
Sinje ReimersDepartment of Cardiac Surgery, Heinrich-Heine-University, Düsseldorf, Germany.
Jonah S SchrauderGerman Primate Center, Functional Imaging Laboratory, Göttingen, Germany.
Lei QuDepartment of Electrical Engineering and Information Technology, South Westphalia University of Applied Sciences, Hagen, Germany.
Xiangge YinDepartment of Electrical Engineering and Information Technology, South Westphalia University of Applied Sciences, Hagen, Germany.
Amir MoussaviGerman Primate Center, Functional Imaging Laboratory, Göttingen, Germany.
Artur LichtenbergDepartment of Cardiac Surgery, Heinrich-Heine-University, Düsseldorf, Germany.
Susann BoretiusGerman Primate Center, Functional Imaging Laboratory, Göttingen, Germany.ORCID https://orcid.org/0000-0003-2792-7423
Michael NeidlinDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-5582-6905
Alexander AssmannDepartment of Cardiac Surgery, Heinrich-Heine-University, Düsseldorf, Germany.ORCID https://orcid.org/0000-0003-3777-7772

Funding

Deutsche Forschungsgemeinschaft AS702/1-1Deutsche Herzstiftung F/18/20
6 · The paper itself

Abstract

objectivesAlthough extracorporeal circulation (ECC) is routinely used in invasive cardiovascular medicine and can cause severe complications, the impact of ECC on arterial blood flow is not yet fully understood. This study aims to reveal actual bloodflow profiles during different ECC scenarios.

methodsTwenty-three New Zealand White rabbits underwent ECC by ante- (n = 7) or retro-grade (n = 9) or physiological perfusion (n = 7). Arterial blood flow profiles were assessed with a focus on cerebral and visceral perfusion. Numerical simulation models were tuned and validated based on magnetic resonance imaging (MRI).

resultsAnte- and retrograde ECC resulted in completely divergent aortic blood flow patterns. Supraaortic and visceral perfusions were not impaired during ante- or retro grade ECC. Excellent correlation of volume flow rates was achieved between MRI and simulations (r = 0.98). Intima damage was observed in regions of high wall shear stress (WSS).

conclusionsThis is the first study assessing arterial blood flow during different ECC scenarios in a living organism, and additionally validating precise blood flow simulations by in vivo measurements. Retrograde ECC does not a priori impair cerebral perfusion. Individualized simulations may guide cannulation strategies aiming at minimization of ECC-related complications.

Indexed as

AortaExtracorporeal CirculationMagnetic Resonance ImagingModels, CardiovascularAnimalsBlood Flow VelocityComputer SimulationHemodynamicsRabbitsRegional Blood Flowanimal‐modelarterial wallblood flowcomputational fluid dynamicsextracorporeal circulationphase contrast magnetic resonance imagingwall shear stress

Identifiers

PMID42026729
PMCPMC13525229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.