ArticleThe clinical respiratory journal2026
Dynamic Parameters within the First 72 H of ICU Admission Predict Extubation Failure and 28-Day Mortality in Severe Pneumonia-Induced ARDS: A Retrospective Cohort Study.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate dynamic parameter changes within 72 h of intensive care unit (ICU) admission for predicting extubation failure and 28-day mortality in patients with severe pneumonia-induced acute respiratory distress syndrome (ARDS).
methodsThis retrospective cohort study enrolled 424 adults with severe pneumonia-induced ARDS receiving invasive ventilation ≥ 48 h during January 2023-August 2025. We collected clinical data and calculated 72-h changes (Δ) in key parameters: physiological stress [maximum respiratory rate (RR), mean heart rate (HR)] and disease progression [ΔPaO
resultsExtubation failure and 28-day mortality rates were 23.82% (101/424) and 29.48% (125/424), respectively. For extubation failure, independent risk factors included older age, higher APACHE II score at admission, immunosuppression, higher maximum RR, higher mean HR, and increased ΔBLA, ΔPCT, and ΔSOFA (protective factor: increased ΔPaO
conclusionDynamic parameters within 72 h of ICU admission are predictors of extubation failure and 28-day mortality in severe pneumonia-induced ARDS, offering a tool for early risk stratification. Extubation failure was also strongly associated with increased short-term mortality, underscoring its clinical significance as an adverse outcome during the disease course.
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